ERBB3 (v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian))

The ERBB3 promoter region is GC rich (65%) and, like EGFR, does not contain a TATA box. A proximal promoter was observed within 600 bp flanking Exon1. AP2-1 (OB2-1) and Fox3a have been demonstrated to be functional transcriptional regulators at upstream start sites (Skinner and Hurst, 1993). A Sox10 regulated enhancer has been identified at chr12:5476306554763421 in neural crest derived cells. The human ERBB3 gene is transcribed as a 6.2 kb message of 4080 nucleotides and 1342 codons specifying the full-length protein. There are four additional alternate transcripts of 1.6, 1.7, 2.1 and 2.3 kb generated by intron read through. At least three of these transcripts code for truncated, secreted soluble forms of ERBB3 (Lee and Maihle, 1998).